Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Wed, Dec 18, 2024
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Volume 14, Issue 1 (5-2000)
Med J Islam Repub Iran 2000 |
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TORABI-NEZHAD S, MAFTOUN S. THE INCI DENC E OF PROS TATIC INTRAEPI THELIAL NEOPLASIA IN PROSTATIC HYPERPLASIA AND PROS TATIC C ARCINOMA. Med J Islam Repub Iran 2000; 14 (1) :9-13
URL: http://mjiri.iums.ac.ir/article-1-892-en.html
URL: http://mjiri.iums.ac.ir/article-1-892-en.html
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R.lran.
Abstract: (4179 Views)
Prostatic intra-epithelial neoplasia (PIN) is considered a precursor of invasive
carcinoma, characterized by proliferation and anaplasia of cells lining prostatic
ducts and acini. In this study, we applied the PIN grading system on one-hundred
cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia,
then compared the results. 74% of prostatic carcinoma and 51 % of prostatic
hyperplasia cases showed PIN foci. Most of the prostatic carcinomas (61 %)
showed foci of high-grade PIN including grade II (46%) and grade III (15%). In
benign prostatic hyperplasia cases, only PIN grade I (26%) and grade II (25%)
were seen.
It is concluded that PIN and invasive adenocarcinoma of prostate are closely
associated and the likelihood for coexistence is higher in patients with high grade
PIN and especially if other factors such as prostate specific antigen and positive
findings on sonography are also considered.
Keywords: Prostate, Prostatic intra-epithelial neoplasia, Prostatic carcinoma, Benign prostatic hyperplasia.
Type of Study: Original Research |
Subject:
Pathology
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