REZAYAT M, HOSSEINI H, AKHONDIAN J, VAHDATI N, ZARRINDAST M. INFLUENCE OF CCK RECEPTOR AGONIST AND ANTAGONISTS ON TOLERANCE INDUCED TO ANTIPENTYLENETETRAZOL ACTIVITY OF DIAZEPAM . Med J Islam Repub Iran 1999; 12 (4) :365-369
URL:
http://mjiri.iums.ac.ir/article-1-989-en.html
From the Department of Pharmacology, Tehran and Mashhad Universities of Medical Sciences, I.R. Iran.
Abstract: (4257 Views)
In the present study, the effects of caerulein and CCK receptor antagonist< on
tolerance to the anti-pentylenetetrazol activity of diazepam has been studied.
Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered
intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48
h after the last dose of diazepam, a test dose of diazepam was tested for antipentylenetetrazol
activity. When animals were treated with caerulein or the CCK
receptor antagonists MK -329 and L-365,260, only L-365,260 reversed the tolerance
to diazepam.
It may be concluded that CCK-B receptor mechanisms may interact with
tolerance induced by diazepam.